2-Chloro-5-hydroxypyridine → HCID 24765339, compound

HRID 658318Notes

Reaction equation

HRID 658318 reaction equation
C[O:2][C:3](=[O:21])[CH2:4][CH2:5][NH:6][C:7](=[O:20])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH2:18][OH:19])[CH2:15][CH2:16][CH3:17])=[CH:10][CH:9]=1.Cl[C:23]1[N:28]=[CH:27][C:26](O)=[CH:25][CH:24]=1.[F:30][C:31]([F:42])([F:41])[C:32]1[CH:37]=[CH:36][C:35](B(O)O)=[CH:34][CH:33]=1>>[F:30][C:31]([F:42])([F:41])[C:32]1[CH:37]=[CH:36][C:35]([C:23]2[N:28]=[CH:27][C:26]([O:19][CH2:18][CH:14]([C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:2])=[O:21])=[O:20])=[CH:9][CH:10]=3)[CH2:15][CH2:16][CH3:17])=[CH:25][CH:24]=2)=[CH:34][CH:33]=1

Participants

4

Reactant 3

HCID 8198212-Chloro-5-hydroxypyridineHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 67485977HCID 67485977, compound

Product 1

HCID 24765339HCID 24765339, compound

Procedure

The title compound is prepared by essentially following the procedures as described in Example 21, using 3-[4-(1-hydroxymethyl-butyl)-benzoylamino]-propionic acid methyl ester and 6-chloro-pyridin-3-ol as starting materials in Step A, followed by 4-trifluoromethyl phenyl boronic acid in Step B. MS (ES): 499.2 [M+H]−.

Sources & evidence

ORD record
ord-3f3cf62c62eb4d299013cbf0e7917d8a
Source dataset
uspto-grants-2011_12
Patent number
US08076374B2

Reaction notes

Loading…