HCID 66744672, compound → HCID 66743967, compound

HRID 658345Notes

Reaction equation

HRID 658345 reaction equation
C([O:5][C:6]1[CH:7]=[C:8]([C@@H:19]([OH:32])[CH2:20][NH:21][C:22]([CH3:31])([CH3:30])[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:9]2[S:13][C:12]([O:14]C(C)C)=[N:11][C:10]=2[CH:18]=1)(C)(C)C>C(O)=O>[CH3:31][C:22]([NH:21][CH2:20][C@@H:19]([C:8]1[C:9]2[S:13][C:12](=[O:14])[NH:11][C:10]=2[CH:18]=[C:6]([OH:5])[CH:7]=1)[OH:32])([CH3:30])[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 1

HCID 66744672HCID 66744672, compound

Product 1

HCID 66743967HCID 66743967, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

(R)-1-(5-tert-Butoxy-2-isopropoxy-benzothiazol-7-yl)-2-(1,1-dimethyl-2-phenyl-ethylamino)-ethanol (40 mg) is stirred in formic acid (2 ml) for 72 hours. The formic acid is removed in vacuo and the title compound is obtained by reversed phase column chromatography using a Jones Flashmaster Personal™ flash chromatography system (ISOLUTE FLASH C18, gradient elution AcCN/water 0 to 50%). MS (ES+) m/e 359.26 (MH+) LCT57144

Workup

  1. customThe formic acid is removed in vacuo

Sources & evidence

ORD record
ord-a24d44ec94884951ba613de8fa514f98
Source dataset
uspto-grants-2011_12
Patent number
US08076489B2

Reaction notes

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