Hydrochloric Acid → HCID 135900450, compound

HRID 658365Notes

Reaction equation

HRID 658365 reaction equation
C([O:3][C:4]1[NH:5][C:6]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][C:10]=2[NH:15][C:16]2[CH:21]=[CH:20][C:19]([I:22])=[CH:18][C:17]=2[F:23])=[N:7][N:8]=1)C.Cl>>[F:23][C:17]1[CH:18]=[C:19]([I:22])[CH:20]=[CH:21][C:16]=1[NH:15][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:9]=1[C:6]1[NH:5][C:4](=[O:3])[NH:8][N:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178467501HCID 178467501, compound

Product 1

HCID 135900450HCID 135900450, compound

Conditions

Temperature
90 °C

Procedure

[4-(5-Ethoxy-4H-[1,2,4]triazol-3-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine (80 mg) was added conc. HCl (4 mL). The reaction mixture was stirred at 90° C. for 4 hr, cooled and filtered, the solid was washed with water and methanol. Yield: white solid 30 mg. LC-MS (Method A) [5.23 min; 398(M+1)]

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. washthe solid was washed with water and methanol
  4. customLC-MS (Method A) [5.23 min; 398(M+1)]

Sources & evidence

ORD record
ord-3c9ba56626eb40489b36f6413082802c
Source dataset
uspto-grants-2011_12
Patent number
US08076486B2

Reaction notes

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