反应详情

温度

120 °C

To a solution of (2-Fluoro-4-iodo-phenyl)-[4-(5-methylsulfanyl-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-amine (100 mg, 0.23 mmol) in dioxane (5 mL) were added morphline (101 mg, 1.17 mmol). The reaction mixture was stirred at 120° C. for 8 h. The solvent was evaporated, residue was purified with prep plate (CH2Cl2:MeOH=20:1 5% TEA), collected product 24 mg. LC-MS (Method A) [5.20 min; 468(M+1)]

1. customThe solvent was evaporated
2. customresidue was purified with prep plate (CH2Cl2:MeOH=20:1 5% TEA)
3. customcollected product 24 mg
4. customLC-MS (Method A) [5.20 min; 468(M+1)]