HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 658366Generated: October 28, 2026
Morpholine → (2-Fluoro-4-iodo-phenyl)-[4-(5-morpholin-4-yl-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-amine
https://huagongshe.com/reaction/658366
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | (2-Fluoro-4-iodo-phenyl)-[4-(5-methylsulfanyl-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-amine | HCID 24890085 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2-Fluoro-4-iodo-phenyl)-[4-(5-morpholin-4-yl-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-amine | HCID 24890249 | — |
Reaction Steps
To a solution of (2-Fluoro-4-iodo-phenyl)-[4-(5-methylsulfanyl-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-amine (100 mg, 0.23 mmol) in dioxane (5 mL) were added morphline (101 mg, 1.17 mmol). The reaction mixture was stirred at 120° C. for 8 h. The solvent was evaporated, residue was purified with prep plate (CH2Cl2:MeOH=20:1 5% TEA), collected product 24 mg. LC-MS (Method A) [5.20 min; 468(M+1)]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08076486B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-64828edf3229482d9aaa795c05767033 |
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| Source note | uspto-grants-2011_12 |
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