反应详情

To a solution of {5-[3-(2-Fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester (400 mg, 0.85 mmol, 1 eq) in THF (5 mL) LiBH4 (37 mg, 1.7 mmol, 2 eq) was added. The reaction mixture was stirred at RT for 20 hrs and then quenched with methanol and then added water. The solvent was partially removed and EtOAc was added. A solid precipitated out that was filtered to give the desired product (190 mg). LC/MS (Method A) [4.48 min; 442(M+1)]

1. customquenched with methanol
2. customThe solvent was partially removed
3. additionEtOAc was added
4. customA solid precipitated out
5. filtrationthat was filtered