反应详情

To a solution of {5-[3-(2-Fluoro-4-iodo-phenylamino)-pyridin-4-yl]-[1,3,4]oxadiazol-2-ylamino}-acetic acid methyl ester (262 mg, 0.56 mmol, 1 eq) in THF-H2O (1:1) (2 mL) LiOH (27 mg, 1.12 mmol, 2 eq) was added. The reaction mixture was stirred at RT for 2 hrs. The solvent was removed partially and more water was added. The mixture was washed with ether and the pH of the aqueous layer was adjusted to 3 with 1N HCl. A solid precipitated and filtered to afford the desired product (190 mg). LC/MS (Method A) [4.83 min; 456(M+1)]

1. customThe solvent was removed partially
2. additionmore water was added
3. washThe mixture was washed with ether
4. customA solid precipitated
5. filtrationfiltered