Lithium Hydroxide → HCID 59026774, compound

Participants

Reaction Steps

To a solution of ethyl 3-{3-[(2-fluoro-4-iodophenyl)amino]pyridin-4-yl}-1,2,4-oxadiazole-5-carboxylate (1.80 g; 3.96 mmol; 1.00 eq.) in THF-H2O (1:1) was added lithium hydroxide (0.19 g; 7.93 mmol) Stirred for 2 h at room temperature. After work up, 1.42 g of (2-Fluoro-4-iodo-phenyl)-(4-[1,2,4]oxadiazol-3-yl-pyridin-3-yl)-amine was obtained in 92% yield. MS m/z: 383 M+1

Provenance & Evidence