Lithium Hydroxide → HCID 59026774, compound

HRID 658392Notes

Reaction equation

HRID 658392 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:15]=1[C:16]1[N:20]=[C:19](C(OCC)=O)[O:18][N:17]=1.[OH-].[Li+]>C1COCC1.O>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:15]=1[C:16]1[N:20]=[CH:19][O:18][N:17]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 68826050HCID 68826050, compound

Product 1

HCID 59026774HCID 59026774, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

To a solution of ethyl 3-{3-[(2-fluoro-4-iodophenyl)amino]pyridin-4-yl}-1,2,4-oxadiazole-5-carboxylate (1.80 g; 3.96 mmol; 1.00 eq.) in THF-H2O (1:1) was added lithium hydroxide (0.19 g; 7.93 mmol) Stirred for 2 h at room temperature. After work up, 1.42 g of (2-Fluoro-4-iodo-phenyl)-(4-[1,2,4]oxadiazol-3-yl-pyridin-3-yl)-amine was obtained in 92% yield. MS m/z: 383 M+1

Sources & evidence

ORD record
ord-4da59368c8d74b3981f3ed481e6a99d3
Source dataset
uspto-grants-2011_12
Patent number
US08076486B2

Reaction notes

Loading…