4-Aminophenol → HCID 59987497, compound

HRID 658470Notes

Reaction equation

HRID 658470 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4].N[C:20]1C=CC(O)=CC=1>>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][C:13]=2[CH3:20])[CH:8]=[CH:7][N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 4034-AminophenolHCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

Product 1

HCID 59987497HCID 59987497, compound

Procedure

The title compound was prepared in the same manner described for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide, substituting 4-amino-2-methylphenol for 4-aminophenol. 1H-NMR (DMSO-d6) δ 8.73 (br q, J=4.8 Hz, 1H), 8.43 (d, J=5.4 Hz, 1H), 7.26 (d, J=2.4 Hz, 1H), 7.02 (dd, J=5.7, 2.7 Hz, 1H), 7.76 (d, J=8.1 Hz, 1H), 6.52 (d, J=3 Hz, 1H), 6.47 (dd, J=8.7, 2.7 Hz, 1H), 5.09 (s, 2H), 2.78 (d, J=3.3 Hz, 3H), 1.91 (s, 3H).

Sources & evidence

ORD record
ord-f2896c3c78164ce1b1a5872b4323ad33
Source dataset
uspto-grants-2011_12
Patent number
US08076488B2

Reaction notes

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