2-amino-N-methylacetamide hydrochloride → HCID 58385419, compound

HRID 658483Notes

Reaction equation

HRID 658483 reaction equation
[CH3:1][NH:2][C:3]([CH2:5][NH:6][C:7]([C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=2)[CH:12]=[CH:11][N:10]=1)=[O:8])=[O:4].Cl.N[CH2:25]C(NC)=O>>[CH3:1][N:2]([CH3:25])[C:3]([CH2:5][NH:6][C:7]([C:9]1[CH:14]=[C:13]([O:15][C:16]2[CH:17]=[CH:18][C:19]([NH2:22])=[CH:20][CH:21]=2)[CH:12]=[CH:11][N:10]=1)=[O:8])=[O:4]

Participants

3

Reactant 2

HCID 138422022-amino-N-methylacetamide hydrochlorideHCID 684295774-(4-Aminophenoxy)pyridine-2-carboxylic acid methylcarbamoylmethylamide

Product 1

HCID 58385419HCID 58385419, compound

Procedure

The title compound was prepared in the same manner described for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylcarbamoylmethylamide, substituting 2-amino-N,N′-dimethylacetamide hydrochloride for 2-amino-N-methylacetamide hydrochloride. 1H-NMR (DMSO-d6) δ 8.75 (t, J=4.8 Hz, 1H), 8.49 (d, J=5.4 Hz, 1H), 7.33 (d, J=2.7 Hz, 1H), 7.32 (d, J=2.7 Hz, 1H), 6.86 (d, J=8.7 Hz, 2H), 6.63 (d, J=9.0 Hz, 2H), 5.18 (s, 2H), 4.11 (d, J=5.4 Hz, 2H), 2.96 (s, 3H), 2.85 (s, 3H); MS LC-MS [M+H]+=315.

Sources & evidence

ORD record
ord-b67ebb49ea4f45389e0d4a8751588112
Source dataset
uspto-grants-2011_12
Patent number
US08076488B2

Reaction notes

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