反应详情

The title compound was prepared in the same manner described for 5-(4-amino-3-fluorophenoxy)-N-methylnicotinamide, substituting 5-(4-aminophenoxy)nicotinic acid methyl ester for 5-(4-amino-3-fluorophenoxy)nicotinic acid methyl ester. 1H NMR (DMSO-d6) δ 8.65 (m, 2H), 8.40 (d, J=2.7 Hz, 1H), 7.52 (t, J=2.2 Hz, 1H), 6.84 (d, J=8.7 Hz, 2H), 6.62 (d, J=8.7 Hz, 2H), 5.01 (s, 2H), 2.75 (d, J=4.4 Hz, 3H); MS LC-MS [M+H]+=244.2, RT=0.29 min.