反应详情

Into a reactor were introduced 10 ml of water containing 4.8g of solid sodium hydroxide, 30 ml of methanol and 75.6g (0.02 mol) of 2-(3',5'-dimethoxy-4'-benzenesulphonyloxy-phenyl)-indole. The reaction medium was heated to 50°-55° C., was stirred for 1 hour and was poured into an aqueous solution of hydrochloric acid. The indole derivative was extracted with ether and the ethereal phase was washed with water to neutrality, dried, treated with charcoal and, finally concentrated under reduced pressure to give 2-(3',5'-dimethoxy-4'-hydroxy-phenyl)-indole which was recrystallized from a mixture of ethanol-acetone 60/40.

1. temperatureThe reaction medium was heated to 50°-55° C.
2. extractionThe indole derivative was extracted with ether
3. washthe ethereal phase was washed with water to neutrality
4. customdried
5. additiontreated with charcoal
6. concentrationfinally concentrated under reduced pressure