4-((2-Fluorophenyl)methoxy)benzaldehyde → 3,4,5-Trimethoxybenzaldehyde

HRID 658808Notes

Reaction equation

HRID 658808 reaction equation
FC1C=CC=CC=1C[C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14]C1C=CC=CC=1F)[CH:8]=[O:9].FC1C=C(C=CC=1)CC1C=C(C=CC=1OCC1C=CC=C(F)C=1)[CH:34]=[O:35].FC1C=CC=CC=1[CH2:54][O:55]C1C=CC(C=O)=CC=1>FC1C=C(C=CC=1)COC1C=CC(C=O)=CC=1>[CH3:34][O:35][C:11]1[CH:10]=[C:7]([CH:6]=[C:5]([O:55][CH3:54])[C:12]=1[O:13][CH3:14])[CH:8]=[O:9]

Participants

5

Reactant 3

HCID 7027174-((2-Fluorophenyl)methoxy)benzaldehydeHCID 866315744-[(3-Fluorophenyl)methoxy]-3-[(3-fluorophenyl)methyl]benzaldehyde2×HCID 866493293-(2-Fluorobenzyl)-4-(2-fluorobenzyloxy)benzaldehyde2×

Product 1

HCID 68583,4,5-Trimethoxybenzaldehyde

Reagents, catalysts & solvents 1

HCID 8801194-[(3-Fluorophenyl)methoxy]benzaldehydeSolvent

Procedure

Calculate the percent content of 3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)benzaldehyde in the 4-(2-fluorobenzyloxy)benzaldehyde examined or of the 3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzaldehyde in the 4-(3-fluorobenzyloxy)benzaldehyde examined by internal standard calculation. The value of the limit of quantitation (LOQ) for (3-(2-fluorobenzyl)-4-(2-fluorobenzyloxy)benzaldehyde and of 3-(3-fluorobenzyl)-4-(3-fluorobenzyloxy)benzaldehyde is 0.005% by weight. The value of the limit of detection (LOD) for both considered impurities is 0.0025% by weight.

Sources & evidence

ORD record
ord-ba50b8b132004859921261c756d6a36f
Source dataset
uspto-grants-2011_12
Patent number
US08076515B2

Reaction notes

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