Phthalimide → HCID 57956805, compound

HRID 658897Notes

Reaction equation

C1(=O)NC(=O)C2=CC=CC=C12.[OH:12][C@H:13]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][CH2:35][C:36]([OH:43])([CH2:40][CH2:41][CH3:42])[CH2:37]CC)[CH:29]=1)[C@@H:14]([CH3:27])[CH2:15][N:16]1C(=O)C2C(=CC=CC=2)C1=O>>[NH2:16][CH2:15][C@@H:14]([CH3:27])[C@H:13]([C:28]1[CH:29]=[C:30]([CH:31]=[CH:32][CH:33]=1)[CH2:34][CH2:35][C:36]1([OH:43])[CH2:37][CH2:42][CH2:41][CH2:40]1)[OH:12]

Participants

Reactant 2

HCID 6809Phthalimide

HCID 57956741HCID 57956741, compound

Product 1

HCID 57956805HCID 57956805, compound

Procedure

Phthalimide cleavage of 2-((2S,3S)-3-hydroxy-3-(3-(3-hydroxy-3-propylhexyl)phenyl)-2-methylpropyl)isoindoline-1,3-dione is performed following the method described in Example 9 gives Example 180.

Workup

customgives Example 180

Sources & evidence

ORD record: ord-91f60c111301435d9e9de12384af60e3
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08076516B2

Reaction notes

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