反应详情

A mixture of chiral (2′S, 3S, 4′R)-6-chloro-4′-[5-chloro-2-(1-hydroxycarbonyl-1-methyl-ethoxy)-phenyl]-2′-(5-fluoro-2-methyl-phenyl) spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (30 mg, 0.052 mmol) and Lawesson's Reagent (40 mg, 0.09 mmol) in THF (1 mL) was stirred at room temperature for 3 h, then purified by flash column to give the title compound as white solid (7 mg).

1. custompurified by flash column