2-(4-Chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-ethyl-butyric acid methyl ester → 2-(4-Chloro-2-formyl-phenoxy)-2-ethyl-butyric acid methyl ester

Participants

Reaction Steps

A solution of 2-(4-chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-ethyl-butyric acid methyl ester (16 g, 48.8 mmol) in trifluoroacetic acid (20 mL) was stirred at room temperature for 3 h. Then the mixture was concentrated and the residue was partitioned between EtOAc and water. The organic layer was washed with 1N NaOH solution, water, dried over anhydrous Na2SO4 and concentrated to give the title compound (13 g).

Provenance & Evidence