反应详情

A solution of 2-(4-chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-ethyl-butyric acid methyl ester (16 g, 48.8 mmol) in trifluoroacetic acid (20 mL) was stirred at room temperature for 3 h. Then the mixture was concentrated and the residue was partitioned between EtOAc and water. The organic layer was washed with 1N NaOH solution, water, dried over anhydrous Na2SO4 and concentrated to give the title compound (13 g).

1. concentrationThen the mixture was concentrated
2. customthe residue was partitioned between EtOAc and water
3. washThe organic layer was washed with 1N NaOH solution, water
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated