反应详情

A solution of 8.66 g (29.8 mmol) 3-[4-(4-Nitro-phenoxy)-pyrimidin-2-ylamino]-propan-1-ol in a mixture of 173 ml THF and 173 ml methanol was hydrogenated over 3.46 g of 10% palladium on charcoal for 8 h. The catalyst was filtered off and the filtrate evaporated. The obtained oil was treated with a small amount of THF and the precipitate removed by filtration. Evaporation of the filtrate gave an oil that was purified by chromatography on silica (dichloromethane/ethanol 95:5) to give 5.77 g (74%) of 3-[4-(4-Amino-phenoxy)-pyrimidin-2-ylamino]-propan-1-ol as colorless oil.

1. filtrationThe catalyst was filtered off
2. customthe filtrate evaporated
3. additionThe obtained oil was treated with a small amount of THF
4. customthe precipitate removed by filtration
5. customEvaporation of the filtrate
6. customgave an oil that
7. customwas purified by chromatography on silica (dichloromethane/ethanol 95:5)