反应详情

149 mg (0.92 mmol) 1,1′-Carbonyl-diimidazol (CDI) were given to a solution of 148 mg (0.838 mmol) 3-trifluoromethoxyaniline in 4.0 ml dichloromethane and stirred for 12 h. A solution of 218 mg (0.838 mmol) 3-[4-(4-Amino-phenoxy)-pyrimidin-2-ylamino]-propan-1-ol in 6 ml dichloromethane was added and the mixture stirred for 12 h at r.t. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel (dichloromethane/methanol 95:5). The obtained material was washed with dichloromethane, the precipitate was isolated by filtration and dried. Yield: 140 mg (36%) of the title compound.

1. stirringthe mixture stirred for 12 h at r.t
2. customThe reaction mixture was evaporated
3. customthe residue was purified by chromatography on silica gel (dichloromethane/methanol 95:5)
4. washThe obtained material was washed with dichloromethane
5. customthe precipitate was isolated by filtration
6. customdried