反应详情

温度

80 °C

Intermediate (e) (18.0 g, 65.2 mmol) was added to an ice bath cooled solution of NaOEt (32.6 mL) (21% by weight in EtOH) in absolute EtOH (41.7 mL) under a nitrogen atmosphere. The ice bath was removed and the mixture was heated at 80° C. for about 12 h until the condensation was complete as observed by TLC. The mixture was poured onto ice/water and extracted into EtOAc. The solvent was dried with Na2SO4, filtered, and evaporated to afford crude intermediate (f) as an off white solid (14.05 g) which was carried on without purification.

1. customThe ice bath was removed
2. additionThe mixture was poured onto ice/water
3. extractionextracted into EtOAc
4. dry with materialThe solvent was dried with Na2SO4
5. filtrationfiltered
6. customevaporated