6-Amino-1,3-naphthalenedisulfonic acid → 6,6'-[5-Nitro-1,3-phenylenebis(carbonylimino)]bis[1,3-naphthalenedisulfonic acid] tetrasodium salt

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Reaction Steps

An 18.18 g portion of 6-amino-1,3-naphthalenedisulfonic acid is suspended in 200 ml of water and the pH is adjusted to 7.0 giving a solution. A 5.6 g portion of sodium acetate is dissolved in this solution and 8.18 g of 5-nitro-1,3-benzenedicarbonyl dichloride is added. The mixture is stirred for one hour, filtered and the filtrate is treated with activated carbon. The filtrate is reduced to a low volume on a rotary evaporator producing crystals. The crystals are recrystallized from water giving 6,6'-[5-nitro-1,3-phenylenebis(carbonylimino)]bis[1,3-naphthalenedisulfonic acid] tetrasodium salt.

Provenance & Evidence