HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → HCID 59191982, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2,2-Difluoropropan-1-amine--hydrogen chloride (1/1) | HCID 2758355 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59191982 | HCID 59191982 | — |
Reaction Steps
TEA (1.3 mL, 0.8 mmol) was added to a solution of 2,2-difluoropropylamine hydrochloride (82 mg, 0.62 mmol) and 1,1′-CARBONYLDIIMIDAZOLE (114 mg, 0.7 mmol) in DMF (3 mL) (clear colorless solution). The solution was used for the synthesis of compound 5 without further isolation of compound 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08080556B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-d6bf13c3ad9545e193edef99561fac83 |
| Source note | uspto-grants-2011_12 |