1,1'-Carbonyldiimidazole → HCID 59191982, compound

HRID 659050Notes

Reaction equation

HRID 659050 reaction equation
Cl.[F:2][C:3]([F:7])([CH3:6])[CH2:4][NH2:5].[C:8](N1C=CN=C1)([N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)=[O:9]>CN(C=O)C>[F:2][C:3]([F:7])([CH3:6])[CH2:4][NH:5][C:8]([N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1)=[O:9]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 27583552,2-Difluoropropan-1-amine--hydrogen chloride (1/1)

Product 1

HCID 59191982HCID 59191982, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

TEA (1.3 mL, 0.8 mmol) was added to a solution of 2,2-difluoropropylamine hydrochloride (82 mg, 0.62 mmol) and 1,1′-CARBONYLDIIMIDAZOLE (114 mg, 0.7 mmol) in DMF (3 mL) (clear colorless solution). The solution was used for the synthesis of compound 5 without further isolation of compound 9.

Sources & evidence

ORD record
ord-d6bf13c3ad9545e193edef99561fac83
Source dataset
uspto-grants-2011_12
Patent number
US08080556B2

Reaction notes

Loading…