反应详情

温度

150 °C

A mixture of 8-(cyclopentyloxy)-4-hydroxy-7-methoxyquinolin-2(1H)-one (350 mg, 1.3 mmol), ammonium acetate (4.0 g, 52 mmol), and anhydrous m-xylene (10 mL) was heated at 150° C. under N2 for 48 h and then allowed to cool to rt. The mixture was concentrated to dryness, diluted with water (25 mL), stirred for 2 min, sonicated for 1 min, and then stirred for 5 min. The free-flowing solid was filtered, washed with water (25 mL), and pumped to dryness to give 4-amino-8-(cyclopentyloxy)-7-methoxyquinolin-2(1H)-one: MS (ESI): 274.9.

1. temperatureto cool to rt
2. concentrationThe mixture was concentrated to dryness
3. additiondiluted with water (25 mL)
4. customsonicated for 1 min
5. stirringstirred for 5 min
6. filtrationThe free-flowing solid was filtered
7. washwashed with water (25 mL)