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Methanol → 3-(3-[2-Oxo-2-(5-phenyl-furan-2-yl)-ethyl]-phenyl)-acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-{3-[2-Oxo-2-(5-phenyl-furan-2-yl)-ethyl]-phenyl}-acrylic acid methyl ester | HCID 68414671 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-(3-[2-Oxo-2-(5-phenyl-furan-2-yl)-ethyl]-phenyl)-acrylic acid | HCID 68414665 | — |
反応手順
The ester (26) (222 mg, 0.64 mmol) was hydrolysed using Method C, except that MeOH (1 mL), THF (1 mL) and 1 M NaOH (1 mL) were used, and the reaction was stirred for 1.5 hours. After work-up, the crude product was triturated with DCM/heptane (×3) to provide the title compound. Yield: 134 mg; LC tr 1.39 min; HPLC Purity: 92%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08080567B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-4735d2e03eb14a6da61e9c1a565f2ac2 |
| 出典メモ | uspto-grants-2011_12 |