Acetic Anhydride → Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 3,5,7-trimethyl-

HRID 65914Notes

Reaction equation

HRID 65914 reaction equation
[CH3:1][N:2]1[C:9]([NH:10][OH:11])=[CH:8][C:6](=[O:7])[N:5]([CH3:12])[C:3]1=[O:4].[C:13](OC(=O)C)(=O)[CH3:14]>>[CH3:13][C:14]1[O:11][N:10]=[C:9]2[C:8]=1[C:6](=[O:7])[N:5]([CH3:12])[C:3](=[O:4])[N:2]2[CH3:1]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 27859331,3-Dimethyl-6-hydroxylaminouracil

Product 1

HCID 100470Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 3,5,7-trimethyl-

Procedure

One gram of 1,3-dimethyl-6-hydroxyaminouracil is boiled with 10 ml of acetic anhydride at 140° C. for 1 hour and, when hot, the insolubles are filtered off. The filtrate is concentrated to dryness to recover 0.7 g of the captioned compound as colorless needles. As recrystallized from ethanol, the compound melts at 200°-202° C.

Workup

  1. filtrationwhen hot, the insolubles are filtered off
  2. concentrationThe filtrate is concentrated to dryness
  3. customto recover 0.7 g of the captioned compound as colorless needles
  4. customAs recrystallized from ethanol

Sources & evidence

ORD record
ord-325744882a9341599ac683156f0a193a
Source dataset
uspto-grants-1978_12
Patent number
US04129654

Reaction notes

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