1,3-Dimethyl-6-hydroxylaminouracil → Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 5,7-dimethyl-

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Reaction Steps

A mixture of 2 g of 1,3-dimethyl-6-hydroxyaminouracil, 20 ml of dimethylformamide and 20 ml of ethyl orthoformate is boiled at 160° C. for 1 hour, after which the solvent is distilled off. To the residue is added ethanol and the resultant crystals are collected by filtration. As recrystallized from hot water, 1.0 g of the captioned compound is obtained as colorless prisms, melting point: 170°-171° C.

Provenance & Evidence