1-Phenyl-3-methyl-6-hydroxyaminouracil → 5-Methyl-7-phenyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione

HRID 65916Notes

Reaction equation

HRID 65916 reaction equation
[C:1]1([N:7]2[C:14]([NH:15][OH:16])=[CH:13][C:11](=[O:12])[N:10]([CH3:17])[C:8]2=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:18]([O-])([O-])OCC>CN(C)C=O>[CH3:17][N:10]1[C:11](=[O:12])[C:13]2=[CH:18][O:16][N:15]=[C:14]2[N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]1=[O:9]

Participants

4

Reactant 2

HCID 123805981-Phenyl-3-methyl-6-hydroxyaminouracilHCID 53630039Ethylorthoformate

Product 1

HCID 123806255-Methyl-7-phenyl-5H,7H-isoxazolo[3,4-d]pyrimidine-4,6-dione

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2 g of 1-phenyl-3-methyl-6-hydroxyaminouracil, 100 ml of dimethylformamide and 10 ml of ethyl orthoformate is reacted in the same manner as Example 11 to obtain 0.93 g of the captioned compound. melting point: 219°-221° C.

Workup

  1. customis reacted in the same manner as Example 11

Sources & evidence

ORD record
ord-52b06a879b3f4a12b05b1d2e8c733e56
Source dataset
uspto-grants-1978_12
Patent number
US04129654

Reaction notes

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