反应详情

A solution of ethyl bromopyruvate (32.76 g, 0.172 m) and 4-methylquinazoline (15.61g, 0.109 m) in dry ethanol (400 ml) was heated at reflux for 16 hours during which time a yellow precipitate formed. The reaction mixture was cooled and the solid filtered and dried to yield crude product. Crystallization from MeOH afforded the product as a yellow solid; m.p. 274°-275° C.

1. temperatureat reflux for 16 hours during which time a yellow precipitate
2. customformed
3. temperatureThe reaction mixture was cooled
4. filtrationthe solid filtered
5. customdried
6. customto yield crude product
7. customCrystallization from MeOH