Ethyl bromopyruvate → 2-Carbethoxy-1H-pyrrolo[1,2-c]quinazolin-4-ium bromide

Participants

Reaction Steps

A solution of ethyl bromopyruvate (32.76 g, 0.172 m) and 4-methylquinazoline (15.61g, 0.109 m) in dry ethanol (400 ml) was heated at reflux for 16 hours during which time a yellow precipitate formed. The reaction mixture was cooled and the solid filtered and dried to yield crude product. Crystallization from MeOH afforded the product as a yellow solid; m.p. 274°-275° C.

Provenance & Evidence