1,4-Dibromobutane → cis-(2-Pyrrolidin-1-yl-cyclopentyl)-carbamic acid tert-butyl ester

HRID 659194Notes

Reaction equation

HRID 659194 reaction equation
[CH3:1][C:2]([O:5][C:6](=[O:14])[NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[NH2:13])([CH3:4])[CH3:3].Br[CH2:16][CH2:17][CH2:18][CH2:19]Br>>[C:2]([O:5][C:6](=[O:14])[NH:7][C@@H:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[N:13]1[CH2:19][CH2:18][CH2:17][CH2:16]1)([CH3:1])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 22667934tert-Butyl (2-aminocyclopentyl)carbamate

Product 1

HCID 66681979cis-(2-Pyrrolidin-1-yl-cyclopentyl)-carbamic acid tert-butyl ester

Procedure

The title compound, brown oil, MS: m/e=255.3 [(M+H)+], was prepared in accordance with the general method of intermediate E from [(1RS,2SR)-2-aminocyclopentyl-carbamic acid 1,1-dimethylethyl ester (CAS 365996-19-6) and 1,4-dibromobutane.

Sources & evidence

ORD record
ord-2c3105996ab4451980f828fbe77c59ba
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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