Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate → 2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65922Notes

Reaction equation

HRID 65922 reaction equation
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]>CO.O=[Pt]=O>[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[NH:11][CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 4407258Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate

Product 1

HCID 227563502-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

The product of Example II (2.5 g, 0.01 m) was dissolved in MeOH (250 ml). The catalyst, PtO2 (0.5 g), was added and the mixture was hydrogenated at 42 p.s.i. for 3 hrs. Filtration and removal of the solvent in vacuo yielded a white solid. Crystallization from MeOH afforded the product as a white solid; m.p. 140°-141° C.

Workup

  1. filtrationFiltration and removal of the solvent in vacuo
  2. customyielded a white solid
  3. customCrystallization from MeOH

Sources & evidence

ORD record
ord-d50ec719b5ab40d785f03502f8272481
Source dataset
uspto-grants-1978_12
Patent number
US04129653

Reaction notes

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