2-Methoxy-6-(trifluoromethyl)benzoic acid → cis-2-Methoxy-N-(2-pyrrolidin-1-yl-cyclopentyl)-6-trifluoromethyl-benzamide

HRID 659274Notes

Reaction equation

HRID 659274 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[C:15]=1[C:16](O)=[O:17]>>[CH3:12][O:13][C:14]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[C:15]=1[C:16]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:17]

Participants

3

Reactant 2

HCID 150175332-Methoxy-6-(trifluoromethyl)benzoic acidHCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×

Product 1

HCID 66680571cis-2-Methoxy-N-(2-pyrrolidin-1-yl-cyclopentyl)-6-trifluoromethyl-benzamide

Procedure

The title compound, off-white solid, MS: m/e=357.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-methoxy-6-trifluoromethylbenzoic acid.

Sources & evidence

ORD record
ord-680d009f7c2c4c76b436e60c80e2abf4
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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