cis-2-Pyrrolidin-1-yl-cyclopentylamine → 2-Cyclopropyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

HRID 659297Notes

Reaction equation

HRID 659297 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([C:28]([F:31])([F:30])[F:29])[C:16]=2[C:17](O)=[O:18])[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([C:28]([F:29])([F:30])[F:31])[C:16]=2[C:17]([NH:11][C@@H:7]2[CH2:8][CH2:9][CH2:10][C@@H:6]2[N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[O:18])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 581677652-Cyclopropyl-4,6-bis-trifluoromethyl-benzoic acid

Product 1

HCID 510012332-Cyclopropyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

Procedure

The title compound, off-white solid, MS: m/e=435.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-cyclopropyl-4,6-bis-trifluoromethyl-benzoic acid (intermediate AN).

Sources & evidence

ORD record
ord-4d228e2b632641d4b5be18c79d6ceed8
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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