2-Methylthio-4,6-bis(trifluoromethyl)benzoic acid → HCID 51001237, compound

HRID 659301Notes

Reaction equation

HRID 659301 reaction equation
[CH:1]1([NH:6][CH:7]2[CH2:11][CH2:10][CH2:9][CH:8]2[NH2:12])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:13][S:14][C:15]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[C:20]([C:28]([F:31])([F:30])[F:29])[C:16]=1[C:17](O)=[O:18]>>[CH:1]1([NH:6][C@H:7]2[CH2:11][CH2:10][CH2:9][C@H:8]2[NH:12][C:17](=[O:18])[C:16]2[C:20]([C:28]([F:29])([F:30])[F:31])=[CH:21][C:22]([C:24]([F:25])([F:26])[F:27])=[CH:23][C:15]=2[S:14][CH3:13])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 593478222-Methylthio-4,6-bis(trifluoromethyl)benzoic acidHCID 66681699HCID 66681699, compound

Product 1

HCID 51001237HCID 51001237, compound

Procedure

The title compound, light pink solid, MS: m/e=455.3 [(M+H)+], was prepared in accordance with the general method of example 5 from (1RS,2SR)-N-Cyclopentyl-cyclopentane-1,2-diamine (intermediate AE) and 2-methylthio-4,6-bis(trifluoromethyl)benzoic acid (CAS 896120-49-3).

Sources & evidence

ORD record
ord-44967390e2f642c18f5d07a59e3844c0
Source dataset
uspto-grants-2011_12
Patent number
US08080541B2

Reaction notes

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