Ethanol → HCID 178485011, compound

HRID 65946Notes

Reaction equation

HRID 65946 reaction equation
CS(=[N:7][S:8]([CH3:11])(=[O:10])=[O:9])C(=S)OC.C[C:13]1[N:14]=[CH:15][NH:16][C:17]=1[CH2:18][S:19][CH2:20][CH2:21][NH2:22].[CH3:23][NH2:24].[CH2:25](O)[CH3:26]>>[CH3:11][S:8]([NH:7][C:15]([NH:14][CH3:13])=[N:16][CH2:17][CH2:18][S:19][CH2:20][C:21]1[NH:22][CH:23]=[N:24][C:25]=1[CH3:26])(=[O:9])=[O:10]

Participants

5

Reactant 4

HCID 702EthanolHCID 6329MethylamineHCID 86734341Methanesulfonyliminodithiocarbonic acid dimethyl esterHCID 178433288HCID 178433288, compound

Product 1

HCID 178485011HCID 178485011, compound

Procedure

A solution of N-methanesulphonyliminodithiocarbonic acid dimethyl ester (10.0 g.) and 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (8.5 g.) in ethanol (100 ml.) was stirred at room temperature for 3 hours. Excess ethanolic methylamine was added and stirring continued for 3 hours at room temperature. Concentration and trituration with ice-water afforded N-methanesulphonyl-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine (12.7 g.), m.p. 133°-134° (from water)

Workup

  1. concentrationConcentration and trituration with ice-water

Sources & evidence

ORD record
ord-ecbc972c44414260bb4f78b6a46423b3
Source dataset
uspto-grants-1978_12
Patent number
US04129657

Reaction notes

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