Hydrochloric Acid → HCID 67996296, compound

Participants

Reaction Steps

A 100-mL round-bottomed flask was charged with a solution of tert-butyl 3-(1H-pyrazol-4-yl)piperidine-1-carboxylate (3.6 g, 14.34 mmol, 1.00 equiv) in 1,4-dioxane (20 mL) and hydrogen chloride (6M, 20 mL). The resulting solution was heated to reflux for 1 hour. Upon completion, the resulting mixture was cooled down and concentrated on a rotary evaporator affording 3-(1H-pyrazol-4-yl)piperidine hydrochloride as white solid (1.5 g, 47%).

Provenance & Evidence