Hydrochloric Acid → HCID 67996296, compound

HRID 659638Notes

Reaction equation

HRID 659638 reaction equation
[NH:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH:3]=[N:2]1.[ClH:19]>O1CCOCC1>[ClH:19].[NH:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]2)[CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67996186HCID 67996186, compound

Product 1

HCID 67996296HCID 67996296, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 100-mL round-bottomed flask was charged with a solution of tert-butyl 3-(1H-pyrazol-4-yl)piperidine-1-carboxylate (3.6 g, 14.34 mmol, 1.00 equiv) in 1,4-dioxane (20 mL) and hydrogen chloride (6M, 20 mL). The resulting solution was heated to reflux for 1 hour. Upon completion, the resulting mixture was cooled down and concentrated on a rotary evaporator affording 3-(1H-pyrazol-4-yl)piperidine hydrochloride as white solid (1.5 g, 47%).

Workup

  1. temperatureThe resulting solution was heated
  2. temperatureto reflux for 1 hour
  3. temperatureUpon completion, the resulting mixture was cooled down
  4. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-634a886fbe3e44aa902760fc1c2e9e99
Source dataset
uspto-grants-2011_12
Patent number
US08080566B1

Reaction notes

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