反应详情

A 250-mL round-bottom flask was charged with 2-nitrobiphenyl-4-carbaldehyde (6.5 g, 28.63 mmol, 1.00 equiv), PPh3 (18.8 g, 71.76 mmol, 2.50 equiv) and 1,2-dichlorobenzene (70 mL). The resulting solution was refluxed for 18 hours. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography eluted with ethyl acetate/petroleum ether (1:30) affording 9H-carbazole-2-carbaldehyde as yellow solid (3.7 g, 66%).

1. temperatureThe resulting solution was refluxed for 18 hours
2. concentrationThe resulting mixture was concentrated under vacuum
3. customThe residue was purified by silica gel column chromatography
4. washeluted with ethyl acetate/petroleum ether (1:30)