Benzonitrile → HCID 178418369, compound

Temperature

100 °C

A solution of benzonitrile (60.0 g, 581.9 mmol, 1.00 equiv) in DMF (anhydrous) (600 mL) was placed in a flask that had been purged and maintained with an inert atmosphere of nitrogen. Ammonium chloride (40.5 g, 757.2 mmol, 1.30 equiv) was added, followed by the addition of lithium chloride (2.0 g, 47.2 mmol, 0.08 equiv). To the mixture was added azidosodium (49.4 g, 756.8 mmol, 1.30 equiv). The resulting solution was stirred overnight, while maintaining the temperature at 100° C. The solids were filtered out and washed with EtOAc. The filtrates were combined and concentrated under vacuum. The residue was dissolved in 350 ml of 10% NaOH aqueous solution. The resulting solution was extracted with 100 mL of EtOAc and the aqueous layers were combined. The pH value of the solution was adjusted to 2 with concentrated HCl. The solids were filtered out and dried over reduced pressure to yield 78.0 g (91%) of 5-phenyl-1H-tetrazole as a white solid. ES m/z: [M+H]+ calcd for C7H6N4, 147.1; found 147.1.

1. customthat had been purged
2. temperaturemaintained with an inert atmosphere of nitrogen
3. filtrationThe solids were filtered out
4. washwashed with EtOAc
5. concentrationconcentrated under vacuum
6. dissolutionThe residue was dissolved in 350 ml of 10% NaOH aqueous solution
7. extractionThe resulting solution was extracted with 100 mL of EtOAc
8. filtrationThe solids were filtered out
9. customdried over reduced pressure

ORD record

ord-8c11f9650c2842bda9db9a8d0ae8ed25

Source dataset

uspto-grants-2011_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08080572B2