N-(2-Methyl-5-nitrophenyl)acetamide → 4-[2-(2-Methyl-5-nitro-phenylamino)-oxazol-5-yl]-benzonitrile

HRID 659741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 659741
NC1C=CC(C)=C(NC2O[C:11]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:12][N:13]=2)C=1.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:25]=1[NH:33][C:34](=[O:36])C.NC1C=CC(C)=C(NC(=O)C)C=1>>[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:25]=1[NH:33][C:34]1[O:36][C:11]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=2)=[CH:12][N:13]=1

Komponenten

4

Edukt 3

HCID 76144N-(2-Methyl-5-nitrophenyl)acetamideHCID 794922-Acetylamino-4-aminotolueneHCID 177573464-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile

Produkt 1

HCID 248719944-[2-(2-Methyl-5-nitro-phenylamino)-oxazol-5-yl]-benzonitrileAusbeute 83 %

Versuchsvorschrift

The same procedure outlined above in the preparation of 4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile was used. However N-(2-methyl-5-nitro-phenyl)-acetamide was used instead N-(5-Amino-2-methyl-phenyl)-acetamide. Yield=83%. m.p.>228° C.

Quellen und Nachweise

ORD-Eintrag
ord-0d109a57438c4e769d56ccca9a07b43d
Quelldatensatz
uspto-grants-2011_12
Patentnummer
US08080669B2

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