2',3'-Acetoxylidide → 4-[2-(2,3-Dimethyl-phenylamino)-oxazol-5-yl]-benzonitrile

HRID 659744Notes

Reaction equation

HRID 659744 reaction equation
N[C:2]1[CH:3]=[CH:4][C:5]([CH3:22])=[C:6]([NH:8][C:9]2[O:10][C:11]([C:14]3[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=3)=[CH:12][N:13]=2)[CH:7]=1.[CH3:23]C1C(C)=CC=CC=1NC(=O)C.NC1C=CC(C)=C(NC(=O)C)C=1>>[CH3:22][C:5]1[C:4]([CH3:23])=[CH:3][CH:2]=[CH:7][C:6]=1[NH:8][C:9]1[O:10][C:11]([C:14]2[CH:21]=[CH:20][C:17]([C:18]#[N:19])=[CH:16][CH:15]=2)=[CH:12][N:13]=1

Participants

4

Reactant 3

HCID 86562',3'-AcetoxylidideHCID 794922-Acetylamino-4-aminotolueneHCID 177573464-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile

Product 1

HCID 248719974-[2-(2,3-Dimethyl-phenylamino)-oxazol-5-yl]-benzonitrileYield 91%

Procedure

The same procedure outlined above in the preparation of 4-[2-(5-Amino-2-methyl-phenylamino)-oxazol-5-yl]-benzonitrile was used. However N-(2,3-dimethylphenyl)-acetamide was used instead N-(5-amino-2-methyl-phenyl)-acetamide. Yield=91%.

Sources & evidence

ORD record
ord-17c3566efc694075a5cd1784ca2abf72
Source dataset
uspto-grants-2011_12
Patent number
US08080669B2

Reaction notes

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