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HRID659829

反应详情

EQUATION

反应方程式

HRID 659829 的结构方程式

REACTANTS

反应物

1
结构：C=CCCC[C@@H]1C[C@H]1OC(=O)N[C@H](C(=O)N1C[C@H](Oc2nc3cc(OC)ccc3nc2C=C)C[C@H]1C(=O)OC)C(C)(C)C
HCID67304070

L-Proline, 3-methyl-N-[[[(1R,2R)-2-(4-penten-1-yl)cyclopropyl]oxy]carbonyl]-L-valyl-4-[(3-ethenyl-7-methoxy-2-quinoxalinyl)oxy]-, methyl ester, (4R)-

C32H42N4O7

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)O[C@@H]1C[C@H]1CCC/C=C/c1nc3ccc(OC)cc3nc1O2
HCID67304410

未命名化合物

收率 25%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

A solution (0.02 M) of methyl 3-methyl-N-({[(1R,2R)-2-pent-4-en-1-ylcyclopropyl]oxy}carbonyl)-L-valyl-(4R)-4-[(7-methoxy-3-vinylquinoxalin-2-yl)oxy]-L-prolinate in DCE was heated to 80° C. then treated with Zhan 1 catalyst (0.15 eq). The resulting mixture was stirred at 80° C. for 1 h, then cooled to room temperature and concentrated under reduced pressure. The residue was purified by flash chromatography (20-50% EtOAc/petroleum ether) to give the title compound (25% for 2 steps) as a foam. MS (ES+) m/z 567 (M+H)+

WORKUP

后处理

  1. temperaturecooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by flash chromatography (20-50% EtOAc/petroleum ether)