Diphenyl Ether → HCID 178479971, compound

HRID 65987Notes

Reaction equation

HRID 65987 reaction equation
[CH3:1][N:2]1[N:6]2[C:7](=[O:17])[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:10]=[C:5]2[CH:4]=[CH:3]1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[CH3:1][N:2]1[CH:3]=[C:4]2[C:5]([N:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:8]=[C:7]2[OH:17])=[N:6]1

Participants

3

Reactant 2

HCID 7583Diphenyl EtherHCID 3702423Pyrazolo[1,5-a]pyrimidin-7(1H)-one, 1-methyl-5-phenyl-

Product 1

HCID 178479971HCID 178479971, compound

Procedure

152 g. of 1-methyl-5-phenylpyrazolo[1,5-a]pyrimidin-7(1H)-one (0.67 mol.) in 500 ml. of diphenyl ether are heated at 250°, while stirring, for 90 minutes. After standing overnight, the crystallized 2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridin-4-ol is filtered off, washed with ether and dried at 70°, yield; 146.6 g. (96%); m.p.241°-243°. A sample recrystallized from acetonitrile melts at 242°-244°.

Workup

  1. waitAfter standing overnight
  2. filtrationthe crystallized 2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridin-4-ol is filtered off
  3. washwashed with ether
  4. customdried at 70°
  5. customA sample recrystallized from acetonitrile melts at 242°-244°

Sources & evidence

ORD record
ord-9d7c6e578eba408ab156a0747c07f088
Source dataset
uspto-grants-1978_12
Patent number
US04129738

Reaction notes

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