Methylamine → HCID 70625931, compound

HRID 65989Notes

Reaction equation

HRID 65989 reaction equation
[Cl:1][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][NH2:19]>>[ClH:1].[CH3:18][NH:19][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][N:14]1[C:4]2=[N:5][C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:7][CH:2]=[C:3]2[CH2:16][N:15]1[CH3:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 22756855HCID 22756855, compound

Product 2

HCID 70625931HCID 70625931, compoundHCID 131710884HCID 131710884, compound

Procedure

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo [3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

Workup

  1. customthe solution is evaporated in vacuo
  2. extractionthe residue is extracted with chloroform
  3. extractionTo the chloroform extract
  4. additionis added ethereal hydrochloric acid

Sources & evidence

ORD record
ord-bcf835d3b3d24125adbc8e58bae80fc5
Source dataset
uspto-grants-1978_12
Patent number
US04129738

Reaction notes

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