反应详情

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo [3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

1. customthe solution is evaporated in vacuo
2. extractionthe residue is extracted with chloroform
3. extractionTo the chloroform extract
4. additionis added ethereal hydrochloric acid