反应详情

5-{2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethyloxy]-benzoyloxy}-1,3-dimethylpyrazole (0.65 g) was dissolved in acetonitrile (10 ml), triethylamine (0.33 g) and acetone cyanohydrin (40 mg) were added thereto and the mixture was stirred at room temperature for 12 hours. The solvent was distilled off, acidified by the addition of diluted hydrochloric acid and extracted with ethyl acetate (150 ml). The organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate. Ethyl acetate was distilled off to obtain objective 4-{2,4-dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoyl}-1,3-dimethyl-5-hydroxy-pyrazole (0.59 g).

1. distillationThe solvent was distilled off
2. additionacidified by the addition of diluted hydrochloric acid
3. extractionextracted with ethyl acetate (150 ml)
4. washThe organic layer was washed with saturated brine
5. dry with materialdried with anhydrous magnesium sulfate
6. distillationEthyl acetate was distilled off