反应详情

80 g (74.6 mmoles) of pyridine-4-carboxaldehyde is dissolved in 150 mL of methanol. 123.5 mL (112 mmoles) of trimethyl orthoformiate is added to the reaction mixture at room temperature followed by the addition of 33 mL of concentrated sulfuric acid. The reaction mixture is kept under reflux for 24 hours and once cooled, added to 300 mL of sodium methylate solution. The white suspension obtained is filtered over celite, the filtrate is concentrated under vacuum and 70.3 g of 4-dimethoxymethyl-pyridine is obtained as a yellow oil.

1. addition123.5 mL (112 mmoles) of trimethyl orthoformiate is added to the reaction mixture at room temperature
2. temperatureunder reflux for 24 hours
3. temperatureonce cooled
4. customThe white suspension obtained
5. filtrationis filtered over celite
6. concentrationthe filtrate is concentrated under vacuum