反应详情

温度

80 °C

2-Chloro-5-trifluoromethyl-pyridine-N-oxide (17, 4 mmol) was dissolved in freshly distilled POCl3 (4.5 mL). The reaction mixture was heated to 80° C. for 17 h. After cooling to room temperature, the solvent was removed under reduced pressure. Ice was added, and the mixture was allowed to stand for 4 h. The mixture was partition between CH2Cl2 (50 mL) and saturated aqueous NaHCO3. Column chromatography afforded compound 18 as yellow oil (yield: 50%).

1. temperatureAfter cooling to room temperature
2. customthe solvent was removed under reduced pressure
3. additionIce was added
4. customThe mixture was partition between CH2Cl2 (50 mL) and saturated aqueous NaHCO3