Hydrogen Bromide → 3-amino-5,7-dichloro-8-hydroxy-3H-quinazolin-4-one hydrobromide

Participants

Reaction Steps

A solution of 5-3 (60 mg, 0.231 mmol) and 48% aqueous hydrobromic acid (2 mL) was heated at 120° C. for 2 h. The solution was cooled to room temperature and the precipitate was isolated via filtration, washed successively with dichloromethane and diethyl ether, and dried in vacuo to provide 3-amino-5,7-dichloro-8-hydroxy-3H-quinazolin-4-one hydrobromide (5-4) as a white solid (44 mg, 58%).

Provenance & Evidence